Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coevolution of the Hepatitis C Virus Polyprotein Sites in Patients on Combined Pegylated Interferon and Ribavirin Therapy

20 Jan 2011

Abstract excerpt

Genotype-specific sensitivity of the hepatitis C virus (HCV) to interferon-ribavirin (IFN-RBV) combination therapy and reduced HCV response to IFN-RBV as infection progresses from acute to chronic infection suggest that HCV genetic factors and intrahost HCV evolution play important roles in therapy outcomes. HCV polyprotein sequences (n = 40) from 10 patients with unsustainable response (UR) (breakthrough and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Hepatitis C virus research
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21248044
DOI: 10.1128/jvi.02197-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coevolution of the Hepatitis C Virus Polyprotein Sites in Patients on Combined Pegylated Interferon and Ribavirin TherapyPMID 21248044Read ↗

Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans.Semantic proximity Read ↗

Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferonSemantic proximity Read ↗

Epistatic connectivity among HCV genomic sites as a genetic marker of interferon resistance.Semantic proximity Read ↗

Hepatitis C virus envelope glycoprotein signatures are associated with treatment failure and modulation of viral entry and neutralization.Semantic proximity Read ↗

Coordinated evolution of the hepatitis C virus.Semantic proximity Read ↗

Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks.Semantic proximity Read ↗

The evolution of the major hepatitis C genotypes correlates with clinical response to interferon therapy.Semantic proximity Read ↗

Predicting response to hepatitis C therapy.Semantic proximity Read ↗

Quantitative differences between intra-host HCV populations from persons with recently established and persistent infectionsSemantic proximity Read ↗

Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance.Semantic proximity Read ↗

Interaction networks of hepatitis C virus NS4B: implications for antiviral therapySemantic proximity Read ↗

Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.