Article
Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2007
Deforche K, Camacho R, Grossman Z, Silander T, Soares M A, Moreau Y, Shafer R W, Van Laethem K, Carvalho A P, Wynhoven B, Cane P, Snoeck J, Clarke J, Sirivichayakul S, Ariyoshi K, Holguin A, Rudich H, Rodrigues R, Bouzas M B, Cahn P, Brigido L F, Soriano V, Sugiura W, Phanuphak P, Morris L, Weber J, Pillay D, Tanuri A, Harrigan P R, Shapiro J M, Katzenstein D A, Kantor R, Vandamme A-M
Abstract excerpt
Interpretation of Human Immunodeficiency Virus 1 (HIV-1) genotypic drug resistance is still a major challenge in the follow-up of antiviral therapy in infected patients. Because of the high degree of HIV-1 natural variation, complex interactions and stochastic behaviour of evolution, the role of resistance mutations is in many cases not well understood. Using Bayesian network learning of HIV-1 sequence data from...
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