Article
Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy.
Blood - 12 May 2011
Wang Hongjie, Madhusudhan Thati, He Tao, Hummel Björn, Schmidt Simone, Vinnikov Ilya A, Shahzad Khurrum, Kashif Muhammed, Muller-Krebs Sandra, Schwenger Vedat, Bierhaus Angelika, Rudofsky Gottfried, Nawroth Peter P, Isermann Berend
Abstract excerpt
Whereas it is generally perceived to be harmful, enhanced coagulation activation can also convey salutary effects. The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced blood loss or impro...
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