Article
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.
PLoS medicine - 1 Apr 2006
Zeisberg Michael, Khurana Mona, Rao Velidi H, Cosgrove Dominic, Rougier Jean-Philippe, Werner Michelle C, Shield Charles F, Werb Zena, Kalluri Raghu
Abstract excerpt
BACKGROUND: Glomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans. Mutations or deletions involving alpha3(IV), alpha4(IV), or alpha5(IV) chains of type IV collagen in the GBM have been identified as the cause for Alport syndrome in humans, a progressive...
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