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Article

Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura.

Kidney international. Supplement - 1 Feb 2009

Tsai Han-Mou

Abstract excerpt

Recent studies have demonstrated that thrombotic thrombocytopenic purpura (TTP), a serious thrombotic disorder affecting the arterioles and capillaries of multiple organs, is caused by a profound deficiency in the von Willebrand factor cleaving metalloprotease, ADAMTS13. ADAMTS13, a 190-kD plasma protease originating primarily in hepatic stellate cells, prevents microvascular thrombosis by cleaving von Willebrand...

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Topics

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Share to ADAM Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microcirculation

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Share to Purpura, Thrombotic Thrombocytopenic

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Source

Open in PubMed Open full text

Identifiers

PMID: 19180123
DOI: 10.1038/ki.2008.610
PMCID: PMC3158997

Genes

ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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