Article
The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes.
Cancer biology & therapy - 3 Jun 2017
He Hongjuan, Lei Lei, Chen Erfei, Xu Xiaona, Wang Lili, Pan Junqiang, Yang Fangfang, Wang Min, Dong Jing, Yang Jin
Abstract excerpt
Sporadic colorectal cancer (sCRC) is one of the most commonly diagnosed cancers worldwide, but few genetic markers have been identified and used for its early detection. MicroRNAs are diverse cellular regulators in cancer pathogenesis that bind to the 3'-untranslated region (3'-UTR) of their target mRNAs, and variants within the miRNA target sites on sCRC-related genes may influence its pathogenesis. To...
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