Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic variant in microRNA target site of TGF-β signaling pathway increases the risk of colorectal cancer in a Chinese population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2014

Gong Jing, Shen Na, Zhang Hong-Mei, Zhong Rong, Chen Wei, Miao Xiaoping, Guo An-Yuan

Abstract excerpt

Evidence shows that single-nucleotide polymorphisms in microRNA (miRNA) target sites can create, destroy, or modify the miRNA/mRNA binding, therefore modulating gene expression and affecting cancer susceptibility. The transforming growth factor-β (TGF-β) signaling pathway plays a pivotal role in tumor initiation and progression. Intriguingly, recent advances of genome-wide association studies have identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type I
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to MicroRNAs

Share to Polymorphism, Single Nucleotide

Share to Signal Transduction

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 24375256
DOI: 10.1007/s13277-013-1562-9

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic variant in microRNA target site of TGF-β signaling pathway increases the risk of colorectal cancer in a Chinese population.PMID 24375256Read ↗

Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population.Semantic proximity Read ↗

A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk.Semantic proximity Read ↗

Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China.Semantic proximity Read ↗

Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer RiskSemantic proximity Read ↗

A low-frequency variant in SMAD7 modulates TGF-β signaling and confers risk for colorectal cancer in Chinese population.Semantic proximity Read ↗

Genetic variants in the TGFβ-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.Semantic proximity Read ↗

An updated meta-analysis on the association of TGF-β1 gene promoter -509C/T polymorphism with colorectal cancer risk.Semantic proximity Read ↗

Meta-analyses of the associations between four common TGF-β1 genetic polymorphisms and risk of colorectal tumor.Semantic proximity Read ↗

Polymorphisms in the potential functional regions of the TGF-β 1 and TGF-β receptor genes and disease susceptibility in HBV-related hepatocellular carcinoma patients.Semantic proximity Read ↗

Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.Semantic proximity Read ↗

Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer.Semantic proximity Read ↗

A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.