Functional SNP in microRNA-491-5p binding site of MMP9 3'-UTR affects cancer susceptibility.

doi:10.1002/jcb.26471

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Article

Functional SNP in microRNA-491-5p binding site of MMP9 3'-UTR affects cancer susceptibility.

Journal of cellular biochemistry - 1 Jul 2018

Pirooz Homeira Javadi, Jafari Niloofar, Rastegari Mozhdeh, Fathi-Roudsari Mehrnoosh, Tasharrofi Nooshin, Shokri Gelareh, Tamadon Mona, Sazegar Hossein, Kouhkan Fatemeh

Abstract excerpt

MicroRNAs (miRNA) are small RNA molecules that negatively regulate gene expression through base pairing interactions between 3'-UTR of the target mRNAs and seed sequence of miRNA. Any changes in the recognition site could destroy binding sites or modify binding affinity, resulting in evasion from miRNA regulation. A putative binding site for miR-491-5p resides in 3'-UTR of MMP9, and a genetic variant (rs1056628...

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PMID: 29091292
DOI: 10.1002/jcb.26471

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MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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