The association of a single-nucleotide variant in the microRNA-146a with advanced colorectal cancer prognosis.

doi:10.1177/1010428320923856

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Article

The association of a single-nucleotide variant in the microRNA-146a with advanced colorectal cancer prognosis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2020

Santos Jéssica Silva Dos, Zunta Gabriella Lucatto, Negrini Amanda Binatto, Ribeiro Marina Silva Guinda, Martinez Carlos Augusto Real, Ribeiro Marcelo Lima, Lourenço Gustavo Jacob, Ortega Manoela Marques

Abstract excerpt

The aim of this study was to evaluate the association of single-nucleotide variant n.60G>C (rs2910164) of microRNA (miR)-146a, related to suppressing of BRCA1/2 DNA repair protein, with the risk and survival of colorectal cancer patients, as well as miR-146a and BRCA1/2 levels and miR binding efficiency. The genotypes were identified in 125 colorectal cancer patients and 276 controls using TaqMan polymerase chain...

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PMID: 32438863
DOI: 10.1177/1010428320923856

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