Article
Evaluation of NFKB1A variants in patients with knee osteoarthritis.
International journal of immunogenetics - 1 Aug 2013
Hulin-Curtis S L, Sharif M, Bidwell J L, Perry M J
Abstract excerpt
A key feature of osteoarthritis (OA) is articular cartilage loss mediated by numerous catabolic factors including pro-inflammatory cytokines. Cytokine expression is modulated by the nuclear factor κB (NF-κB) family of transcription factors that are in turn, regulated by the inhibitor of NF-κB IκBα encoded by NFKB1A. We examined eight, previously reported common germline polymorphisms to determine whether NFKB1A...
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