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Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.

Arthritis care & research - 1 Dec 2025

McMenamin Katie J, Riley Thomas R, Wipfler Kristin, Michaud Kaleb, Wheeler Austin, England Bryant R, Sauer Brian, Wysham Katherine D, Xiao Rui, March Michael, Cannon Grant W, Toikumo Sylvanus, Kranzler Henry R, Kember Rachel L, Mikuls Ted R, Baker Joshua F

Abstract excerpt

OBJECTIVE: Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA). METHODS: Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training data set) and the Veterans Affairs Rheumatoid...

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PMID: 40583606
DOI: 10.1002/acr.25588
PMCID: PMC12750132

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