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Article

Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.

Arthritis and rheumatism - 1 Feb 2006

Valdes Ana M, Van Oene Mark, Hart Deborah J, Surdulescu Gabriela L, Loughlin John, Doherty Michael, Spector Tim D

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) is recognized to have a genetic component, and in this study, we aimed to replicate in a case-control study of men and women with clinical knee OA genetic associations in 12 candidate genes previously reported to be associated with OA. METHODS: Twenty-five single-nucleotide polymorphisms were genotyped in 298 men and 305 women ages 50-86 who were diagnosed as having knee OA, as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16453284
DOI: 10.1002/art.21621

Genes

ADAM12
CILP
ESR1
NCOR2
TNFAIP6
BMP2
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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