Article
Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.
Thrombosis and haemostasis - 26 Jul 2017
Stroo Ingrid, Zeerleder Sacha, Ding Chao, Luken Brenda M, Roelofs Joris J T H, de Boer Onno J, Meijers Joost C M, Castellino Francis J, van 't Veer Cornelis, van der Poll Tom
Abstract excerpt
Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence during pneumonia and whether this is dependent on FXII activation, we infected in parallel...
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