Article
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.
Blood - 22 Oct 2015
Prasad Joni M, Gorkun Oleg V, Raghu Harini, Thornton Sherry, Mullins Eric S, Palumbo Joseph S, Ko Ya-Ping, Höök Magnus, David Tovo, Coughlin Shaun R, Degen Jay L, Flick Matthew J
Abstract excerpt
Fibrin(ogen) is central to hemostasis and thrombosis and also contributes to multiple physiologic and pathologic processes beyond coagulation. However, the precise contribution of soluble fibrinogen vs insoluble fibrin matrices to vascular integrity, tissue repair, inflammation, and disease has been undefined and unapproachable. To establish the means to distinguish fibrinogen- and fibrin-dependent processes in...
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