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Article

Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.

PloS one - 1 Jan 2011

Guo Yongzhi, Li Jinan, Hagström Elin, Ny Tor

Abstract excerpt

Plasmin has been proposed to be an important mediator during inflammation/infection. In this study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis. Two models were used: an infection model by intravenous injection of 1×10⁷ CFU of S. aureus, and a sepsis model by...

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Identifiers

PMID: 21931850
DOI: 10.1371/journal.pone.0024774
PMCID: PMC3171470

Genes

STAT3

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