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Article

Survival advantage of heterozygous factor V Leiden carriers in murine sepsis.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2015

Kerschen E, Hernandez I, Zogg M, Maas M, Weiler H

Abstract excerpt

BACKGROUND: The high allelic frequency of the prothrombotic Leiden polymorphism in human blood coagulation factor V (FV) has been speculated to reflect positive selection during evolution. Heterozygous Leiden carriers enrolled in the placebo arm of the PROWESS sepsis trial and heterozygous Leiden mice challenged with endotoxin both showed reduced mortality, whereas homozygous Leiden mice were not protected from...

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Identifiers

PMID: 25690763
DOI: 10.1111/jth.12876
PMCID: PMC4542152

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