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Article

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2006

Renckens Rosemarijn, Roelofs Joris J T H, Florquin Sandrine, de Vos Alex F, Pater Jennie M, Lijnen H Roger, Carmeliet Peter, van 't Veer Cornelis, van der Poll Tom

Abstract excerpt

Sepsis is associated with enhanced production of tissue-type plasminogen activator (tPA). We investigated the function of endogenous tPA in the immune responses to Escherichia coli-induced abdominal sepsis using tPA gene-deficient (tPA(-/-)) and normal wild-type (WT) mice. tPA(-/-) mice demonstrated an impaired defense against E. coli peritonitis as indicated by higher bacterial loads at the primary site of the...

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Identifiers

PMID: 16818777
DOI: 10.4049/jimmunol.177.2.1189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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