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Article

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.

Journal of cellular physiology - 1 Nov 2017

Staines Katherine A, Javaheri Behzad, Hohenstein Peter, Fleming Robert, Ikpegbu Ekele, Unger Erin, Hopkinson Mark, Buttle David J, Pitsillides Andrew A, Farquharson Colin

Abstract excerpt

The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone-specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal...

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Identifiers

PMID: 28488815
DOI: 10.1002/jcp.25999
PMCID: PMC5575468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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