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Article

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation.

Bone research - 19 Jul 2025

Wang Jialiang S, Strauss Katelyn, Houghton Caroline, Islam Numa, Yoon Sung-Hee, Kobayashi Tatsuya, Brooks Daniel J, Bouxsein Mary L, Zhao Yingshe, Yee Cristal S, Alliston Tamara N, Wein Marc N

Abstract excerpt

Osteogenesis imperfecta (OI) is a group of diseases caused by defects in type I collagen processing which result in skeletal fragility. While these disorders have been regarded as defects in osteoblast function, the role of matrix-embedded osteocytes in OI pathogenesis remains largely unknown. Homozygous human SP7 (c.946 C > T, R316C) mutation results in a recessive form of OI characterized by fragility...

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Identifiers

PMID: 40683889
DOI: 10.1038/s41413-025-00440-1
PMCID: PMC12276330

Genes

SP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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