Article

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

2021-03-22

Abstract excerpt

Osteocytes use an elaborate network of dendritic connections to control bone remodeling. Some osteoblasts embed within mineralized bone matrix, change shape, and become osteocytes. The molecular circuitry that drives dendrite formation during “osteocytogenesis” is poorly understood. Here we show that deletion of Sp7 , a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed6c4e77-edde-5dae-8236-b6e1bd709550
DOI: 10.1101/2021.03.22.436056

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrinDOI 10.1101/2021.03.22.436056Read

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.Semantic proximity Read

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation.Semantic proximity Read

SP7: from Bone Development to Skeletal Disease.Semantic proximity Read

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal DiseaseSemantic proximity Read

Single‐cell RNA Seq reveals cellular l andscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosisSemantic proximity Read

ZNF687 couples bone marrow myeloid progenitor dynamics to osteoclastogenesis in severe Paget’s disease of boneSemantic proximity Read

A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder.Semantic proximity Read

Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast SpecificationSemantic proximity Read

The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone DiseasesSemantic proximity Read

Compromised alveolar bone cells in a patient with dentinogenesis imperfecta caused by DSPP mutation.Semantic proximity Read

Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7).Semantic proximity Read

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.Semantic proximity Read