Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.

doi:10.1038/s41467-021-26571-7

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Article

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.

Nature communications - 1 Nov 2021

Wang Jialiang S, Kamath Tushar, Mazur Courtney M, Mirzamohammadi Fatemeh, Rotter Daniel, Hojo Hironori, Castro Christian D, Tokavanich Nicha, Patel Rushi, Govea Nicolas, Enishi Tetsuya, Wu Yunshu, da Silva Martins Janaina, Bruce Michael, Brooks Daniel J, Bouxsein Mary L, Tokarz Danielle, Lin Charles P, Abdul Abdul, Macosko Evan Z, Fiscaletti Melissa, Munns Craig F, Ryder Pearl, Kost-Alimova Maria, Byrne Patrick, Cimini Beth, Fujiwara Makoto, Kronenberg Henry M, Wein Marc N

Abstract excerpt

Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing osteocytes. The circuitry that drives dendrite formation during "osteocytogenesis" is poorly understood. Here we show that deletion of Sp7 in osteoblasts and osteocytes causes defects in osteocyte dendrites. Profiling of Sp7 target genes and binding sites reveals unexpected repurposing of this transcription factor to drive...

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Identifiers

PMID: 34725346
DOI: 10.1038/s41467-021-26571-7
PMCID: PMC8560803

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