Article
Craniosynostosis in transgenic mice overexpressing Nell-1.
The Journal of clinical investigation - 1 Sept 2002
Zhang Xinli, Kuroda Shun'ichi, Carpenter Dale, Nishimura Ichiro, Soo Chia, Moats Rex, Iida Keisuke, Wisner Eric, Hu Fei-Ya, Miao Steve, Beanes Steve, Dang Catherine, Vastardis Heleni, Longaker Michael, Tanizawa Katsuyuki, Kanayama Norihiro, Saito Naoaki, Ting Kang
Abstract excerpt
Previously, we reported NELL-1 as a novel molecule overexpressed during premature cranial suture closure in patients with craniosynostosis (CS), one of the most common congenital craniofacial deformities. Here we describe the creation and analysis of transgenic mice overexpressing Nell-1. Nell-1 transgenic animals exhibited CS-like phenotypes that ranged from simple to compound synostoses. Histologically, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.