Article
Lack of Association Between Adrenoreceptor Genotype and the Vasoconstriction Response to Dexmedetomidine.
Seminars in cardiothoracic and vascular anesthesia - 1 Dec 2017
Friesen Robert H, Slavov Dobromir, Miyamoto Shelley D, John Ing Richard, LaRiviere Wells B, Taylor Matthew R G
Abstract excerpt
An exaggerated vasoconstriction response to dexmedetomidine, an α-2 adrenergic agonist, has been associated with 2 genotypes: a deletion in the α-2B adrenoreceptor gene ( ADRA2B deletion) and SNP rs9922316 in the gene for protein kinase C type β ( PRKCB). We hypothesized that children with a marked systemic vascular resistance index (SVRI) increase following intravenous dexmedetomidine bolus would carry these...
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