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Article

The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study.

Brazilian journal of anesthesiology (Elsevier) - 1 Jan 2000

Choi Yoon Ji, Park Kyu Hee, Park Ju Yeon, Min Won Kee, Lee Yoon Sook

Abstract excerpt

BACKGROUND: The genetic polymorphisms of the alpha-2A adrenergic receptor (ADRA2A), which plays a significant role in sedation, anxiety relief, and antinociception, particularly in dexmedetomidine, may differ in the degree of sedation. This study aimed to investigate the effect of the genetic polymorphisms of ADRA2A (rs11195418, rs1800544, rs2484516, rs1800545, rs553668, ) on the sedative effects of...

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Identifiers

PMID: 33915198
DOI: 10.1016/j.bjane.2021.04.005
PMCID: PMC9373641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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