Article
Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline.
Clinical science (London, England : 1979) - 1 May 2003
Snapir Amir, Koskenvuo Juha, Toikka Jyri, Orho-Melander Marju, Hinkka Susanna, Saraste Markku, Hartiala Jaakko, Scheinin Mika
Abstract excerpt
Common naturally occurring polymorphisms have been identified in the coding regions of the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoceptor (AR) genes [alpha(1A)-AR R492C, alpha(2B)-AR insertion/deletion (I/D), beta(1)-AR R389G, beta(2)-AR G16R and beta(2)-AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to...
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