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Article

Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype.

Journal of hypertension - 1 Feb 2010

Muszkat Mordechai, Kurnik Daniel, Sofowora Gbenga G, Solus Joseph, Xie Hong-Guang, Harris Paul A, Williams Scott M, Wood Alastair J J, Stein C Michael

Abstract excerpt

OBJECTIVES: Vascular alpha2B-adrenergic receptors (alpha2B-ARs) mediate vasoconstriction and contribute to peripheral regulation of vascular tone. In vitro, a common 301-303 deletion in the alpha2B-AR gene, ADRA2B, results in loss of alpha2B-AR desensitization. We examined the hypothesis that ADRA2B del301-303 or other common ADRA2B variants alter vascular desensitization in vivo. METHODS: We measured sensitivity...

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Share to Adrenergic alpha-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, alpha-2

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Identifiers

PMID: 20051907
DOI: 10.1097/HJH.0b013e328333d212
PMCID: PMC2895551

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