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Article

A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.

Pharmacotherapy - 1 Jun 2022

Gallaway Katherine A, Skaar Todd C, Biju Ashwin, Slaven James, Tillman Emma M

Abstract excerpt

STUDY OBJECTIVE: Dexmedetomidine is titrated to achieve sedation in the pediatric and cardiovascular intensive care units (PICU and CVICU). In adults, dexmedetomidine response has been associated with an ADRA2A polymorphism (rs1800544); CC genotype is associated with an increased sedative response compared with GC and GG. To date, this has not been studied in children. DESIGN: We conducted a pilot study to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35429176
DOI: 10.1002/phar.2684
PMCID: PMC9325491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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