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Osteosarcomas with H3F3A mutation a clinicopathological and molecular genetic study of 7 cases with review of the literature.

Human pathology - 1 Jul 2026

Wei Qingzhu, Zhong Lin, Zhou Hui, Jiang Lucen, Wang Qi, Li Dan, Lai Siqi, Yang Qiao

Abstract excerpt

Some studies have suggested that osteosarcomas with H3F3A mutations (OS-H3F3A‌) may represent a subtype of primary malignant giant cell tumor of bone (GCTB). Previous research has been limited in case number, highlighting the need for further investigation. In this study, we present seven cases of OS-H3F3A and review an additional 24 documented cases in the literature. Among 189 osteosarcoma cases, we identified...

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Biomarkers, Tumor
Bone Neoplasms
DNA Mutational Analysis
High-Throughput Nucleotide Sequencing
Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

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PMID: 41990998
DOI: 10.1016/j.humpath.2026.106120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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