Heterogeneous Cell Types in Single-cell-derived Clones of MCF7 and MDA-MB-231 Cells.

doi:10.21873/anticanres.11572

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Article

Heterogeneous Cell Types in Single-cell-derived Clones of MCF7 and MDA-MB-231 Cells.

Anticancer research - 1 May 2017

Khan Gul Nabi, Kim Eun Jin, Shin Tae Seop, Lee Sang Ho

Abstract excerpt

BACKGROUND/AIM: Variations in cell phenotype in a single-cell-derived clone may result from asymmetric cell divisions that lead to different cell fate in a homogenous microenvironment. The aim of this study was to demonstrate the extent of cell variety in single-cell-derived clones and propose a different strategy in treating cancer by observed phenotypic heterogeneity in cellular types. Additionally, the role of...

Topics

Antibiotics, Antineoplastic
Breast Neoplasms
Cell Line, Tumor
Doxorubicin
Drug Resistance, Neoplasm
Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
Humans
Luminescent Proteins
Phenotype
Recombinant Proteins
Red Fluorescent Protein

Source

Open in PubMed

Identifiers

PMID: 28476800
DOI: 10.21873/anticanres.11572

Genes

GAPDH
VIM
VCL
PCNA
PXN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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