Article
Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.
Cancer research - 15 Feb 2009
Burga Laura N, Tung Nadine M, Troyan Susan L, Bostina Mihnea, Konstantinopoulos Panagiotis A, Fountzilas Helena, Spentzos Dimitrios, Miron Alexander, Yassin Yosuf A, Lee Bernard T, Wulf Gerburg M
Abstract excerpt
Female BRCA1 mutation carriers have a nearly 80% probability of developing breast cancer during their life-time. We hypothesized that the breast epithelium at risk in BRCA1 mutation carriers harbors mammary epithelial cells (MEC) with altered proliferation and differentiation properties. Using a three-dimensional culture technique to grow MECs ex vivo, we found that the ability to form colonies, an indication of...
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