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Article

Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.

Cancer research - 15 Feb 2009

Burga Laura N, Tung Nadine M, Troyan Susan L, Bostina Mihnea, Konstantinopoulos Panagiotis A, Fountzilas Helena, Spentzos Dimitrios, Miron Alexander, Yassin Yosuf A, Lee Bernard T, Wulf Gerburg M

Abstract excerpt

Female BRCA1 mutation carriers have a nearly 80% probability of developing breast cancer during their life-time. We hypothesized that the breast epithelium at risk in BRCA1 mutation carriers harbors mammary epithelial cells (MEC) with altered proliferation and differentiation properties. Using a...

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Identifiers

PMID: 19190334
DOI: 10.1158/0008-5472.CAN-08-2954
PMCID: PMC3041511

Genes

BRCA1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19190334-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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