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Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin

4 Oct 2013

Abstract excerpt

Tumors are heterogeneous at the cellular level where the ability to maintain tumor growth resides in discrete cell populations. Floating sphere-forming assays are broadly used to test stem cell activity in tissues, tumors and cell lines. Spheroids are originated from a small population of cells with stem cell features able to grow in suspension culture and behaving as tumorigenic in mice. We tested the ability of...

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PMID: 24124614
DOI: 10.1371/journal.pone.0077281

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