Article
Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.
Breast cancer research and treatment - 1 Jul 2011
Kabos Peter, Haughian James M, Wang Xinshuo, Dye Wendy W, Finlayson Christina, Elias Anthony, Horwitz Kathryn B, Sartorius Carol A
Abstract excerpt
A majority of breast cancers are estrogen receptor (ER) positive and have a luminal epithelial phenotype. However, these ER⁺ tumors often contain heterogeneous subpopulations of ER⁻ tumor cells. We previously identified a population of cytokeratin 5 (CK5) positive cells within ER⁺ and progesteron...
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