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Article

4-1BB-Enhanced Expansion of CD8+ TIL from Triple-Negative Breast Cancer Unveils Mutation-Specific CD8+ T Cells.

Cancer immunology research - 1 Jun 2017

Harao Michiko, Forget Marie-Andrée, Roszik Jason, Gao Hui, Babiera Gildy V, Krishnamurthy Savitri, Chacon Jessica A, Li Shumin, Mittendorf Elizabeth A, DeSnyder Sarah M, Rockwood Korrene F, Bernatchez Chantale, Ueno Naoto T, Radvanyi Laszlo G, Vence Luis, Haymaker Cara, Reuben James M

Abstract excerpt

Triple-negative breast cancer (TNBC) highly infiltrated with CD8+ tumor-infiltrating lymphocytes (TIL) has been associated with improved prognosis. This observation led us to hypothesize that CD8+ TIL could be utilized in autologous adoptive cell therapy for TNBC, although this concept has proven to be challenging, given the difficulty in expanding CD8+ TILs in solid cancers other than in melanoma. To overcome...

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Share to Antibodies, Monoclonal
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

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Source

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Identifiers

PMID: 28473315
DOI: 10.1158/2326-6066.CIR-16-0364
PMCID: PMC5525328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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