Article

Enhancing HLA-DR in Cytotoxic T Lymphocytes is crucial for the development of efficient adoptive T cell Therapies for Breast Cancer

2024-09-06

Abstract excerpt

<h4>Background</h4> Despite advances in breast cancer (BC) therapies, more effective interventions are needed, especially for chemotherapy-resistant tumors. Immune checkpoint inhibitors show promise for triple-negative breast cancer, but their effectiveness across all BC subtypes remains challenging. Therefore, novel strategies, including adoptive cellular therapy, employing patients’ own T lymphocytes expanded...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f9989f3-b78b-51ab-974a-e96908cf621f
DOI: 10.1101/2024.09.03.610810

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancing HLA-DR in Cytotoxic T Lymphocytes is crucial for the development of efficient adoptive T cell Therapies for Breast CancerDOI 10.1101/2024.09.03.610810Read

Determination of HLA-DR level in cytotoxic T lymphocytes: a new validated tool to predict breast cancer response to treatmentSemantic proximity Read

Advances in immunotherapy for triple-negative breast cancerSemantic proximity Read

Comparison of the tumor immune microenvironment phenotypes in different breast cancers after neoadjuvant therapy.Semantic proximity Read

A single-cell transcriptomic landscape of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapiesSemantic proximity Read

The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer SubtypesSemantic proximity Read

Identification of cell surface targets for CAR-T cell therapies and antibody–drug conjugates in breast cancerSemantic proximity Read

Multiomic dissection of HR <sup>+</sup> /HER2 <sup>−</sup> invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentationSemantic proximity Read

Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer.Semantic proximity Read

Circulating CD8+ T-cell repertoires reveal the biological characteristics of tumors and clinical responses to chemotherapy in breast cancer patientsSemantic proximity Read

Double-negative T cells with a distinct transcriptomic profile are abundant in the peripheral blood of patients with breast cancerSemantic proximity Read

Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cellsSemantic proximity Read

Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives.Semantic proximity Read