Article
4-1BB-based isolation and expansion of CD8+ T cells specific for self-tumor and non-self-tumor antigens for adoptive T-cell therapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 May 2014
Choi Beom K, Lee Sang C, Lee Myoung J, Kim Young H, Kim Young-Woo, Ryu Keun-Won, Lee Jun-Ho, Shin Su M, Lee Sang-Ho, Suzuki Susumu, Oh Ho S, Kim Chang H, Lee Don G, Hwang Sun H, Yu Eun-Mi, Lee In O, Kwon Byoung S
Abstract excerpt
Adoptive T-cell therapy is a promising approach to the immunotherapy of cancer, but for it to be a general cancer therapy a simple and standardized procedure for producing tumor-specific CD8 T cells is needed. On the basis of a unique property of 4-1BB (CD137), the selective expression on activated T cells, we have developed a simple and practical protocol to produce antigen-specific CD8 T cells from peripheral...
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