Article

Activation-dependent lentiviruses enable antigen-specific T cell expansion and transduction

2026-05-13

Abstract excerpt

Cancer immunotherapies rely on tumor-specific T cells, which arise endogenously in most patients with cancer, but can be low frequency and poorly functional. Methods to specifically identify, expand, and manipulate tumor-specific T cells at the rare frequencies found in peripheral blood would enable new immunotherapeutic strategies. Here, we demonstrate an approach to virally transduce polyclonal tumor-reactive T...

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Literature Corpus work: b3612434-e925-57d7-9975-a86ea61ea066
DOI: 10.64898/2026.05.11.724165

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