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Article

A genome editing approach to study cancer stem cells in human tumors

3 May 2017

Abstract excerpt

The analysis of stem cell hierarchies in human cancers has been hampered by the impossibility of identifying or tracking tumor cell populations in an intact environment. To overcome this limitation, we devised a strategy based on editing the genomes of patientderived tumor organoids using CRISPR/Cas9 technology to integrate reporter cassettes at desired marker genes. As proof of concept, we engineered human...

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PMID: 28468934
DOI: 10.15252/emmm.201707550

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