Article
Reversion of neurovirulent mutations, recombination and high intra-host diversity in vaccine-derived poliovirus excreted by patients with primary immune deficiency.
Journal of medical virology - 1 Sept 2024
Ben Salem Imene, Khemiri Haifa, Drechsel Oliver, Arbi Marwa, Böttcher Sindy, Mekki Najla, Ben Fraj Ilhem, Souiai Oussama, Yahyaoui Mahrez, Ben Farhat Essia, Meddeb Zina, Touzi Henda, Ben Mustapha Imene, BenKahla Alia, Ouederni Monia, Barbouche Mohamed-R, Diedrich Sabine, Triki Henda, Haddad-Boubaker Sondes
Abstract excerpt
Patients with Primary immunodeficiency (PIDs) may be infected by Polioviruses (PVs), especially when vaccinated with live Oral Polio Vaccine before diagnosis. They may establish long-term shedding of divergent strains and may act as reservoirs of PV transmission. This study delved into the effect of the genetic evolution of complete PV genomes, from MHC class II-deficient patients, on the excretion duration and...
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