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Article

Cyclin a-CDK phosphorylation regulates MDM2 protein interactions.

The Journal of biological chemistry - 10 Aug 2001

Zhang T, Prives C

Abstract excerpt

The product of the MDM2 gene interacts with and regulates a number of proteins, in particular the tumor suppressor p53. The MDM2 protein is likely to be extensively modified in vivo, and such modification may regulate its functions in cells. We identified a potential cyclin-dependent kinase (CDK) site in murine MDM2, and found the protein to be efficiently phosphorylated in vitro by cyclin A-containing complexes...

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Share to 3T3 Cells
Share to Cyclin A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 11359766
DOI: 10.1074/jbc.M011326200

Genes

MDM2
CDK2
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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