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Article

Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.

6 Jun 1995

Abstract excerpt

Infection by human immunodeficiency virus type 1 (HIV-1) causes acquired immunodeficiency syndrome (AIDS) after a long clinical latency. This disease is associated with a spectrum of cancers. Here we report that wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits the transcription of p53. Downregulation of p53 by upregulated tat may be important for the...

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PMID: 7777531
DOI: 10.1073/pnas.92.12.5461

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Source receipt: pubmed, retrieved 7 Sept 2026.

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