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Article

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.

Nature - 14 Oct 2004

Arrasate Montserrat, Mitra Siddhartha, Schweitzer Erik S, Segal Mark R, Finkbeiner Steven

Abstract excerpt

Huntington's disease is caused by an abnormal polyglutamine expansion within the protein huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin and by the death of selected types of neuron. Whether inclusion bodies are pathogenic, incidental or a beneficial copin...

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Identifiers

PMID: 15483602
DOI: 10.1038/nature02998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15483602-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.PMID 15483602Read ↗

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation.Semantic proximity Read ↗

Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species.Semantic proximity Read ↗

A cellular model that recapitulates major pathogenic steps of Huntington's disease.Semantic proximity Read ↗

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease.Semantic proximity Read ↗

Threshold inclusion size triggers conversion of huntingtin to prion-like state that is reversible in newly born cellsSemantic proximity Read ↗

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.Semantic proximity Read ↗

Protein aggregates in Huntington's disease.Semantic proximity Read ↗

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington'sdiseaseSemantic proximity Read ↗

Stochastic kinetics of intracellular huntingtin aggregate formation.Semantic proximity Read ↗

Formation of Polyglutamine Inclusions in Non-CNS TissueSemantic proximity Read ↗

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.Semantic proximity Read ↗

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell‐type‐specificSemantic proximity Read ↗

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