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Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

23 Aug 2021

Abstract excerpt

BACKGROUND: FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermentation costs and environmental burdens. Herein, we tried to improve its production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis....

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PMID: 34425854
DOI: 10.1186/s12934-021-01660-w

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