Article
Multiple loci on 8q24 associated with prostate cancer susceptibility.
Nature genetics - 1 Oct 2009
Al Olama Ali Amin, Kote-Jarai Zsofia, Giles Graham G, Guy Michelle, Morrison Jonathan, Severi Gianluca, Leongamornlert Daniel A, Tymrakiewicz Malgorzata, Jhavar Sameer, Saunders Ed, Hopper John L, Southey Melissa C, Muir Kenneth R, English Dallas R, Dearnaley David P, Ardern-Jones Audrey T, Hall Amanda L, O'Brien Lynne T, Wilkinson Rosemary A, Sawyer Emma, Lophatananon Artitaya, Horwich Alan, Huddart Robert A, Khoo Vincent S, Parker Christopher C, Woodhouse Christopher J, Thompson Alan, Christmas Tim, Ogden Chris, Cooper Colin, Donovan Jenny L, Hamdy Freddie C, Neal David E, Eeles Rosalind A, Easton Douglas F
Abstract excerpt
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x...
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