Article
Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.
Journal of the National Cancer Institute - 17 Oct 2007
Zheng S Lilly, Sun Jielin, Cheng Yu, Li Ge, Hsu Fang-Chi, Zhu Yi, Chang Bao-Li, Liu Wennuan, Kim Jin Woo, Turner Aubrey R, Gielzak Marta, Yan Guifang, Isaacs Sarah D, Wiley Kathleen E, Sauvageot Jurga, Chen Huann-Sheng, Gurganus Robin, Mangold Leslie A, Trock Bruce J, Gronberg Henrik, Duggan David, Carpten John D, Partin Alan W, Walsh Patrick C, Xu Jianfeng, Isaacs William B
Abstract excerpt
BACKGROUND: Recent studies have provided evidence of associations between genetic markers at human chromosome 8q24 and an increased risk of prostate cancer. We examined whether multiple independent risk variants exist in this region and whether the strength of observed associations differs as a function of disease aggressiveness. METHODS: We evaluated associations between 18 single-nucleotide polymorphisms (SNPs)...
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