Evaluation of the 8q24 prostate cancer risk locus and MYC expression.

doi:10.1158/0008-5472.CAN-09-0387

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evaluation of the 8q24 prostate cancer risk locus and MYC expression.

Cancer research - 1 Jul 2009

Pomerantz Mark M, Beckwith Christine A, Regan Meredith M, Wyman Stacia K, Petrovics Gyorgy, Chen Yongmei, Hawksworth Dorota J, Schumacher Fredrick R, Mucci Lorelei, Penney Kathryn L, Stampfer Meir J, Chan Jennifer A, Ardlie Kristin G, Fritz Brian R, Parkin Rachael K, Lin Daniel W, Dyke Michelle, Herman Paula, Lee Steve, Oh William K, Kantoff Philip W, Tewari Muneesh, McLeod David G, Srivastava Shiv, Freedman Matthew L

Abstract excerpt

Polymorphisms at 8q24 are robustly associated with prostate cancer risk. The risk variants are located in nonprotein coding regions and their mechanism has not been fully elucidated. To further dissect the function of this locus, we tested two hypotheses: (a) unannotated microRNAs (miRNA) are transcribed in the region, and (b) this region is a cis-acting enhancer. Using next generation sequencing, 8q24 risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, myc

Share to Prostatectomy

Share to Prostatic Neoplasms

Share to Proto-Oncogene Mas

Share to Risk

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 19549893
DOI: 10.1158/0008-5472.CAN-09-0387
PMCID: PMC2884104

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the 8q24 prostate cancer risk locus and MYC expression.PMID 19549893Read ↗

Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.Semantic proximity Read ↗

Multiple regions within 8q24 independently affect risk for prostate cancer.Semantic proximity Read ↗

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.Semantic proximity Read ↗

Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility.Semantic proximity Read ↗

Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility.Semantic proximity Read ↗

An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer.Semantic proximity Read ↗

Multiple loci on 8q24 associated with prostate cancer susceptibility.Semantic proximity Read ↗

Multiple prostate cancer risk variants on 8q24Semantic proximity Read ↗

Identification of a new prostate cancer susceptibility locus on chromosome 8q24.Semantic proximity Read ↗

Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.Semantic proximity Read ↗

Genetic variation at 8q24 as a susceptibility factor for prostate cancer: definitive results from epidemiologic studies?Semantic proximity Read ↗

DNA methylation levels at chromosome 8q24 in peripheral blood are associated with 8q24 cancer susceptibility loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.