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Article

Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse.

Neuroscience - 22 Jan 2015

Ohnishi Y N, Ohnishi Y H, Vialou V, Mouzon E, LaPlant Q, Nishi A, Nestler E J

Abstract excerpt

Previous work has implicated the transcription factor, ΔFosB, acting in the nucleus accumbens, in mediating the pro-rewarding effects of drugs of abuse such as cocaine as well as in mediating resilience to chronic social stress. However, the transgenic and viral gene transfer models used to establish these ΔFosB phenotypes express, in addition to ΔFosB, an alternative translation product of ΔFosB mRNA, termed...

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Identifiers

PMID: 25313003
DOI: 10.1016/j.neuroscience.2014.10.002
PMCID: PMC4268105

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