Article

Oxidation of ΔFOSB at Cys172 Controls Hippocampal Gene Targets and Learning

2025-10-15

Abstract excerpt

Imbalance of reduction/oxidation (redox) in the brain is associated with numerous diseases including Alzheimer’s disease (AD), substance abuse disorders, and stroke. Moreover, cognitive decline can be caused by neuronal dysfunction that precedes cell death, and this dysfunction is in part produced by altered gene expression. However, the mechanisms by which redox state controls gene expression in neurons are not w...

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Literature Corpus work: 6ce4beb8-158a-543f-8571-c5a4e527ebfe
DOI: 10.1101/2025.10.14.682315

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