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Article

Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.

Genetics - 1 Jun 2017

Chen Tai-Di, Rotival Maxime, Chiu Ling-Yin, Bagnati Marta, Ko Jeong-Hun, Srivastava Prashant K, Petretto Enrico, Pusey Charles D, Lai Ping-Chin, Aitman Timothy J, Cook H Terence, Behmoaras Jacques

Abstract excerpt

Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely susceptible Wistar Kyoto (WKY) rat strain, we have identified multiple crescentic glomerulonephritis QTL (Crgn) and positionally cloned genes underlying Crgn1 and Crgn2, which accounted for 40% of total variance in glomerular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28450461
DOI: 10.1534/genetics.116.197376
PMCID: PMC5499168

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