Article
Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2005
Kim Eun-Hee, Lee Chul-Ho, Hyun Byung-Hwa, Suh Jun-Gyo, Oh Yang-Seok, Namikawa Takao, Ishikawa Akira
Abstract excerpt
The FGS/Kist strain of mice, a new animal model for focal glomerulosclerosis (FGS) in humans, was previously established by recurrent selection for high proteinuria, which is a principal marker of FGS, from descendants of CBA/Nga and RFM/Nga strains. We performed a genome-wide scan for quantitative trait loci (QTLs) affecting proteinuria in a population of 356 backcross progeny derived from a cross between...
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