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Article

Association of colorectal cancer with genetic and epigenetic variation in PEAR1-A population-based cohort study.

PloS one - 1 Jan 2022

Yang Wen-Yi, Izzi Benedetta, Bress Adam P, Thijs Lutgarde, Citterio Lorena, Wei Fang-Fei, Salvi Erika, Delli Carpini Simona, Manunta Paolo, Cusi Daniele, Hoylaerts Marc F, Luttun Aernout, Verhamme Peter, Hardikar Sheetal, Nawrot Tim S, Staessen Jan A, Zhang Zhen-Yu

Abstract excerpt

Platelet Endothelial Aggregation Receptor 1 (PEAR1) modulates angiogenesis and platelet contact-induced activation, which play a role in the pathogenesis of colorectal cancer. We therefore tested the association of incident colorectal cancer and genetic and epigenetic variability in PEAR1 among 2532 randomly recruited participants enrolled in the family-based Flemish Study on Environment, Genes and Health...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35390065
DOI: 10.1371/journal.pone.0266481
PMCID: PMC8989234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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